Cellulose-Affinity Isolation of Vaccine Candidate Antigens from Transgenic Plants
نویسندگان
چکیده
منابع مشابه
Computer aided selection of candidate vaccine antigens
Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems of the immune system. To a great extent, immunoinformatics is typified by epitope prediction methods. It has found disappointingly limited use in the design and discovery of new vaccines, whi...
متن کاملExpression of GA733-Fc Fusion Protein as a Vaccine Candidate for Colorectal Cancer in Transgenic Plants
The tumor-associated antigen GA733 is a cell-surface glycoprotein highly expressed in colorectal carcinomas. In this study, 3 recombinant genes were constructed as follows: GA733 tagged to the ER retention sequence KDEL (GA733K), GA733 fused to the immunoglobulin Fc fragment (GA733-Fc), and GA733-Fc fused to the ER retention sequence (GA733-FcK). Agrobacterium-mediated transformation was used t...
متن کاملHighly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.
Vaccine development has been hampered by difficulties in developing new and safe adjuvants, so alternative technologies that offer new avenues forward are urgently needed. The goal of this study was to express a monoclonal recombinant immune complex in a transgenic plant. A recombinant protein consisting of a tetanus toxin C fragment-specific monoclonal antibody fused with the tetanus toxin C f...
متن کاملTransgenic plants as vaccine production systems.
Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes encoding antigens of bacterial and viral pathogens can be expressed in plants ...
متن کاملIdentification of Novel Vaccine Candidate Antigens Using Phage Display Technology
Identification of novel vaccine candidate antigens using phage display technology J. Newcombe and J. McFadden SBLS University of Surrey, Guildford, Surrey, GU2
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Biomolecular Engineering
سال: 2018
ISSN: 2578-8876
DOI: 10.11648/j.cbe.20180301.11